LIPUS healing

How LIPUS Works

How Does LIPUS Affect Fracture Healing?

The fracture repair process is divided into four stages: inflammation, soft callus formation, hard callus formation, and remodeling.22 Low-intensity pulsed ultrasound treatment (LIPUS) has been shown to accelerate fracture healing at every stage, with maximum benefit achieved when applied throughout the entire healing process.22

AccelStim™ uses a low-intensity pulsed ultrasound mechanical pressure wave composed of 1000 pulses per second to stimulate a response at the cellular level.23,24

LIPUS Stimulates Bone Cells to Proliferate, Differentiate, and Mineralize

  • LIPUS stimulates undifferentiated mesenchymal stem cells to differentiate into osteoblasts.28
  • In response to LIPUS, periosteal tissue increases expression of osteocalcin, alkaline phosphatase, and Vascular Endothelial Growth Factor. These resulted in an increase in mineralization and enhanced angiogenesis.29
  • Enhanced stimulation of osteogenic cells by LIPUS drive endochondral ossification.30,31

Bone cells multiplying
bone regeneration

LIPUS Increases New Bone Formation

  • LIPUS increases mineralization and calcium deposition.32,33
  • LIPUS enhances bone formation.34
  • LIPUS improves osteogenic differentiation, mineralization, volume of newly formed bone, and osseointegration.35
  • LIPUS accelerates all stages of the fracture repair process (inflammation, bone formation, and bone remodeling) by increasing mineralization and reducing the inflammatory response.22,36,37